Association of Apolipoprotein A Gene Polymorphism with Uncomplicated Plasmodium falciparum Malaria in Elfasher City, North Darfur, Sudan

Idrise, Alaa Abdallah Adam and Elgoraish, Amanda G. and Ahmed, Rania Tag Elsir and Omer, Nadia Madni Mohamed and Salih, Mohamed A. M. and Ismail, Jamal Ismail Khalifia and Adam, Nassreldeen Khalid Abdelraman and Elzaki, Salaheldein G. (2023) Association of Apolipoprotein A Gene Polymorphism with Uncomplicated Plasmodium falciparum Malaria in Elfasher City, North Darfur, Sudan. Asian Journal of Biochemistry, Genetics and Molecular Biology, 13 (3). pp. 37-45. ISSN 2582-3698

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Abstract

Aims: This study aimed to investigate the lipids profile, APOA genotype with malaria infection. It was hypothesized that the malaria parasite uses cholesterol and phospholipids from its host, resulting in a decrease in serum HDL.

Study Design: A cross-sectional hospital -based study.

Place and Duration of Study: The study was conducted during the transmission season between July to November 2020 in different hospitals and centers in Elfasher city.

Methodology: We included (39 men and 64 female), 57.3% were adults and 42.7% were children, plasmodium falciparum infection, with clinical symptoms and signs of uncomplicated malaria. Parasites density, lipids profile and APOA genotyping were assayed.

Results: The mean level of CHOL and TG was 134.7 mg/dl and 73.0 mg/dl, respectively, and the average levels of LDL and HDL are 56.6 mg/dl and 56.2 mg/dl, respectively. The G/G genotypes of APOA were identified in 94.2% of the patients compared to other APOA genotypes. The overall allele frequency for the G allele was 96.0%, and the T allele was 3.9% using the Hardy-Weinberg distribution.

Conclusion: In conclusions, the lipids profile and APOA genotype were not associated with uncomplicated malaria.

Item Type: Article
Subjects: AP Academic Press > Biological Science
Depositing User: Unnamed user with email support@apacademicpress.com
Date Deposited: 07 Apr 2023 05:17
Last Modified: 12 Sep 2024 04:08
URI: http://info.openarchivespress.com/id/eprint/925

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