THE DERMATOPROTECTIVE ACTIVITY OF DIMEPHOSPHON BY REDUCED BLOOD CIRCULATION WITHIN THE SKIN ON THE BACKGROUND OF THE EXPERIMENTAL DIABETES MELLITUS AND THE EXOGENOUS HYPERCHOLESTEROLEMIA

Aim. The study of Dimephosphon impact on survival of the dermal graft on the pedicle and the fasciocutaneous autograft in the arterial, venous and arteriovenous deficiency on the background of the experimental diabetes mellitus complicated by exogenous hypercholesterolemia.

Material and Methods. In experiments on white rat males with Alloxan diabetes complicated by exogenous hypercholesterolemia the Dimephosphon effect was estimated for survival of the dermal graft on the pedicle (in the back area) and non-free fasciocutaneous autograft (of the anterior abdominal wall) in arterial, venous and arteriovenous circulation deficiency. To estimate dermatoprotective action of Dimephosphon the length the survived dermal draft part and the necrotic area of the non-free fasciocutaneous autograft were measured. In blood serum the glucose rate (by glucose oxidant method with a standard “Glucose-FKD” (Russia) reagents set ), as well as the total cholesterol , triglyceride, high-density lipoprotein cholesterol rate (by “Olmex” standard reagent sets on the FP-901 (Finland) analyzer ) were measured. Extralow and low density lipoprotein cholesterol and also atherogenicity index were calculated with common formulas.

Results. Under accepted experimental conditions Dimephosphon (100mg/kg per day subcutaneously within 14 days) has well-defined dermatoprotective action as well as correcting effect on carbohydrate and lipid metabolism.

Conclusion. Dimephosphon dermatoprotective action can be provided by its ability to be involved in various parts of homeostasis including carbohydrate and lipid metabolism.