ASSESSMENT OF EFFECTIVENESS OF ANTI-RECURRENT AND HORMONAL THERAPY IN WOMEN WITH UTERINE FIBROIDS IN PREGRAVIDAL PREPARATION

KHOROLSKY, V. A. and DRJAEVA, L. G. and MEDVEDEVA, L. A. and BARSUK, A. V. and SAYNOGA, T. V. (2018) ASSESSMENT OF EFFECTIVENESS OF ANTI-RECURRENT AND HORMONAL THERAPY IN WOMEN WITH UTERINE FIBROIDS IN PREGRAVIDAL PREPARATION. Kuban Scientific Medical Bulletin, 25 (4). pp. 90-96. ISSN 1608-6228

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Abstract

Aim. This study was designed to evaluate the effectiveness of sequential prescription of drugs for anti-recurrent therapy of the uterine fibroids (UF) and combined oral contraceptives (COC) in pregravidal preparation.

Materials and methods. There was conducted a prospective, nonrandomized and controlled cohort study of 150 women with UF who are planning a pregnancy after the organ-preserving treatment of uterine fibroids by means of myomectomy with laparoscopic access and pregravidal preparation. The immunohistochemical (IHC) study of the intensity expression of Ki 67, p53, Bcl-2 was performed for the differential diagnosis of reactive proliferation from dysplasia in the distant fibroid node and the selection of anti-recurrent therapy.

Results. The duration of the UF disease does not depend on the intensity of expression of p53, Ki-67 or Bcl-2, the level of expression of the progesterone receptors in the distant fibroid node. A negative average correlation between the level of hemoglobin before myomectomy, the duration of the disease (r = -0.3867) and the number of nodes (r = -0.5389) was revealed. After the end of the anti-recurrent treatment in women who underwent organ- preserving treatment of uterine fibroids, the prescription of COC is connected with a further decrease in the size of fibroid nodes remaining after myomectomy from 15.81±0.22 mm to 8.94±0.45 mm (p<0.05), the number of fibroid nodes from 2.25±0.08 to 0.91±0.06 (р<0.05).

Conclusion. The combination of anti-recurrent therapy with the subsequent prescription of the COC for prevention of the UF growth in women planning a pregnancy after myomectomy with endoscopic access is highly effective.

Item Type: Article
Subjects: AP Academic Press > Medical Science
Depositing User: Unnamed user with email support@apacademicpress.com
Date Deposited: 04 Mar 2023 10:58
Last Modified: 28 May 2024 05:18
URI: http://info.openarchivespress.com/id/eprint/692

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