KHOROLSKY, V. A. and DRJAEVA, L. G. and MEDVEDEVA, L. A. and BARSUK, A. V. and SAYNOGA, T. V. (2018) ASSESSMENT OF EFFECTIVENESS OF ANTI-RECURRENT AND HORMONAL THERAPY IN WOMEN WITH UTERINE FIBROIDS IN PREGRAVIDAL PREPARATION. Kuban Scientific Medical Bulletin, 25 (4). pp. 90-96. ISSN 1608-6228
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Abstract
Aim. This study was designed to evaluate the effectiveness of sequential prescription of drugs for anti-recurrent therapy of the uterine fibroids (UF) and combined oral contraceptives (COC) in pregravidal preparation.
Materials and methods. There was conducted a prospective, nonrandomized and controlled cohort study of 150 women with UF who are planning a pregnancy after the organ-preserving treatment of uterine fibroids by means of myomectomy with laparoscopic access and pregravidal preparation. The immunohistochemical (IHC) study of the intensity expression of Ki 67, p53, Bcl-2 was performed for the differential diagnosis of reactive proliferation from dysplasia in the distant fibroid node and the selection of anti-recurrent therapy.
Results. The duration of the UF disease does not depend on the intensity of expression of p53, Ki-67 or Bcl-2, the level of expression of the progesterone receptors in the distant fibroid node. A negative average correlation between the level of hemoglobin before myomectomy, the duration of the disease (r = -0.3867) and the number of nodes (r = -0.5389) was revealed. After the end of the anti-recurrent treatment in women who underwent organ- preserving treatment of uterine fibroids, the prescription of COC is connected with a further decrease in the size of fibroid nodes remaining after myomectomy from 15.81±0.22 mm to 8.94±0.45 mm (p<0.05), the number of fibroid nodes from 2.25±0.08 to 0.91±0.06 (р<0.05).
Conclusion. The combination of anti-recurrent therapy with the subsequent prescription of the COC for prevention of the UF growth in women planning a pregnancy after myomectomy with endoscopic access is highly effective.
Item Type: | Article |
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Subjects: | AP Academic Press > Medical Science |
Depositing User: | Unnamed user with email support@apacademicpress.com |
Date Deposited: | 04 Mar 2023 10:58 |
Last Modified: | 28 May 2024 05:18 |
URI: | http://info.openarchivespress.com/id/eprint/692 |