Synthesis and Screening of New 5-Substituted-1,3,4-oxadiazole-2-thioglycosides as Potent Anticancer Agents

A .Z. Abu-Zaied, Mamdouh and A. M. Nawwar, Galal and H. Swellem, Randa and H. El-Sayed, Shahinaz (2012) Synthesis and Screening of New 5-Substituted-1,3,4-oxadiazole-2-thioglycosides as Potent Anticancer Agents. Pharmacology & Pharmacy, 03 (02). pp. 254-261. ISSN 2157-9423

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Abstract

A series of newly 1,3,4-oxadiazole-2-thioglycoside derivatives were synthesized. The key step of this protocol is the coupling between 5-herteroaryl-1,3,4-oxadiazole-2-thione and activated sugars (cyclic or acyclic sugar analogues) in the presence of basic medium. Among of the synthesized compounds, compounds 7, 10, 11 and 13 were screened for them in vitro anticancer activity against four human cancer cells. MCF-7 (Breast), HEPG2 (Liver), HCT116 (Colon) and HEP2 (Larynx) carcinoma cell lines with IC50 values ranging from 2.08 - 8.72 μg/well. Compounds 11 and 13 were highly specific and potent for four cell lines (MCF-7, HCT116, HEPG2 and HEP2).

Item Type: Article
Subjects: AP Academic Press > Chemical Science
Depositing User: Unnamed user with email support@apacademicpress.com
Date Deposited: 01 Mar 2023 06:51
Last Modified: 19 Sep 2024 09:10
URI: http://info.openarchivespress.com/id/eprint/635

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