Anti-Aging Effect of Cynara cardunculus L. var. Cynara scolymus L. Extract in D-Galactose-Induced Skin Aging Model in Rats

Sukoyan, Galina and Tsivtsivadze, Edisher and Golovach, Veronika and Kezeli, Tamara and Demina, Natalya (2018) Anti-Aging Effect of Cynara cardunculus L. var. Cynara scolymus L. Extract in D-Galactose-Induced Skin Aging Model in Rats. Pharmacology & Pharmacy, 09 (10). pp. 428-439. ISSN 2157-9423

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Abstract

The aim of the study was to evaluate the efficacy of 2% Cynara scolymus L. extracts in reverse disturbances of collagen metabolism and inflammation in D-galactose induced skin aging model in rats. D-galactose induced aging reproduced in 48 animals of main group, and 12 rats in control group. All animals in main group were randomized for 4 groups: I. aging + saline, II - IV. different manufacturers 2% artichoke extracts (with content of chlorogenic acid < 2.5%) in a dose of intradermal injection 0.13 mg twice at weeks during 4 weeks. Influence of artichoke extracts restored skin relative weight and led to an increase of solubility in neutral salt and acid, and decreased pepsin solubility collagen fraction, restored the hexosamine/collagen (hydroxyproline) ratio and decreased the activity of nuclear transcription factor (NF-kB). Local prolonged treatment with artichoke extracts improved collagen metabolism and attenuated the progression of inflammation in D-galactose induced skin aging model.

Item Type: Article
Subjects: AP Academic Press > Chemical Science
Depositing User: Unnamed user with email support@apacademicpress.com
Date Deposited: 22 Feb 2023 07:51
Last Modified: 12 Aug 2024 10:30
URI: http://info.openarchivespress.com/id/eprint/527

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