The First Approved “Deuterated” Drug: A Short Review of the Concept

Raffa, Robert B. and Pergolizzi, Joseph V. and Taylor, Robert (2018) The First Approved “Deuterated” Drug: A Short Review of the Concept. Pharmacology & Pharmacy, 09 (10). pp. 440-446. ISSN 2157-9423

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Abstract

The first “deuterated” drug has recently been approved by the U.S. FDA (Food & Drug Administration). A “deuterated” drug is a drug in which the hydrogen atom in one or more of the carbon-hydrogen bonds in its chemical structure is replaced by deuterium (“heavy hydrogen”, a hydrogen isotope that has a neutron, i.e., one neutron instead of the usual no neutrons). A carbon-deuterium (C-D) bond is more stable in the body than a carbon-hydrogen (C-H) bond. If the deuterium is strategically located in a drug’s chemical structure, the extra stability of the bond will be more resistant to metabolic breakdown, and the duration of drug action will be prolonged. We review the general concept of deuterated drugs, historical examples of the classes of application, and the new approval.

Item Type: Article
Subjects: AP Academic Press > Chemical Science
Depositing User: Unnamed user with email support@apacademicpress.com
Date Deposited: 22 Feb 2023 07:52
Last Modified: 24 Jul 2024 09:18
URI: http://info.openarchivespress.com/id/eprint/526

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