PK, Md. Moyan Uddin and Islam, Mohammad Sayful and Haque, Shariful and Akther, Lutfa and Pervin, Rumana (2021) Free Radical Scavenging, Enzyme Inhibitory and Anti-Staphylococcus aureus Properties of the Fruiting Bodies of Ganoderma lucidum, Lingzhi Mushroom. Pharmacology & Pharmacy, 12 (03). pp. 73-84. ISSN 2157-9423
pp_2021031915474725.pdf - Published Version
Download (349kB)
Abstract
The current study evaluated the antioxidant, α-amylase inhibitory and anti-Staphylococcus aureus activities of the fruiting bodies of Ganoderma lucidum. Methanolic extract of G. lucidum (MEGL) was investigated for its in vitro antioxidant activity using 1,1-diphenyl 2-picrylhydrazyl (DPPH) assay and EC50 value was determined. α-Amylase inhibitory and anti-S. aureus activities were carried out by conventional methods. The mushroom extract showed maximum free radical scavenging activity at a dose of 500 μg/mL with EC50 value of 22.1399 μg/mL. EC50 value for the inhibition of α-amylase activity was found 22.6011 μg/mL. G. lucidum extracts exhibited a concentration-dependent Anti-S. aureus activity. The vast differences of this inhibition between lower and higher doses were assessed significantly (p < 0.05). This study shows that the fruiting body of G. lucidum has moderate antioxidant, α-amylase inhibitory, and anti-S. aureus activities. Thus this mushroom may be the alternative plant source for the antioxidant, anti-diabetic and antibacterial agents and further in vivo studies and isolation of bioactive compounds are required.
Item Type: | Article |
---|---|
Subjects: | AP Academic Press > Chemical Science |
Depositing User: | Unnamed user with email support@apacademicpress.com |
Date Deposited: | 14 Feb 2023 09:14 |
Last Modified: | 05 Jul 2024 08:09 |
URI: | http://info.openarchivespress.com/id/eprint/510 |