Free Radical Scavenging, Enzyme Inhibitory and Anti-Staphylococcus aureus Properties of the Fruiting Bodies of Ganoderma lucidum, Lingzhi Mushroom

PK, Md. Moyan Uddin and Islam, Mohammad Sayful and Haque, Shariful and Akther, Lutfa and Pervin, Rumana (2021) Free Radical Scavenging, Enzyme Inhibitory and Anti-Staphylococcus aureus Properties of the Fruiting Bodies of Ganoderma lucidum, Lingzhi Mushroom. Pharmacology & Pharmacy, 12 (03). pp. 73-84. ISSN 2157-9423

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Abstract

The current study evaluated the antioxidant, α-amylase inhibitory and anti-Staphylococcus aureus activities of the fruiting bodies of Ganoderma lucidum. Methanolic extract of G. lucidum (MEGL) was investigated for its in vitro antioxidant activity using 1,1-diphenyl 2-picrylhydrazyl (DPPH) assay and EC50 value was determined. α-Amylase inhibitory and anti-S. aureus activities were carried out by conventional methods. The mushroom extract showed maximum free radical scavenging activity at a dose of 500 μg/mL with EC50 value of 22.1399 μg/mL. EC50 value for the inhibition of α-amylase activity was found 22.6011 μg/mL. G. lucidum extracts exhibited a concentration-dependent Anti-S. aureus activity. The vast differences of this inhibition between lower and higher doses were assessed significantly (p < 0.05). This study shows that the fruiting body of G. lucidum has moderate antioxidant, α-amylase inhibitory, and anti-S. aureus activities. Thus this mushroom may be the alternative plant source for the antioxidant, anti-diabetic and antibacterial agents and further in vivo studies and isolation of bioactive compounds are required.

Item Type: Article
Subjects: AP Academic Press > Chemical Science
Depositing User: Unnamed user with email support@apacademicpress.com
Date Deposited: 14 Feb 2023 09:14
Last Modified: 05 Jul 2024 08:09
URI: http://info.openarchivespress.com/id/eprint/510

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