The Functions of Non-coding RNAs in rRNA Regulation

Yan, Qi and Zhu, Chengming and Guang, Shouhong and Feng, Xuezhu (2019) The Functions of Non-coding RNAs in rRNA Regulation. Frontiers in Genetics, 10. ISSN 1664-8021

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Abstract

Ribosomes are ribonucleoprotein machines that decode the genetic information embedded in mRNAs into polypeptides. Ribosome biogenesis is tightly coordinated and controlled from the transcription of pre-rRNAs to the assembly of ribosomes. Defects or disorders in rRNA production result in a number of human ribosomopathy diseases. During the processes of rRNA synthesis, non-coding RNAs, especially snoRNAs, play important roles in pre-rRNA transcription, processing, and maturation. Recent research has started to reveal that other long and short non-coding RNAs, including risiRNA, LoNA, and SLERT (among others), are also involved in pre-rRNA transcription and rRNA production. Here, we summarize the current understanding of the mechanisms of non-coding RNA-mediated rRNA generation and regulation and their biological roles.

Item Type: Article
Subjects: AP Academic Press > Medical Science
Depositing User: Unnamed user with email support@apacademicpress.com
Date Deposited: 08 Feb 2023 07:53
Last Modified: 21 Aug 2024 03:50
URI: http://info.openarchivespress.com/id/eprint/448

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