Hereditary Spastic Paraplegia: From Gene to Clinic

Hasan TONEKABONI, Seyyed (2010) Hereditary Spastic Paraplegia: From Gene to Clinic. Iranian Journal of Child Neurology, 3 (4). pp. 7-16.

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Abstract

Objective

Hereditary Spastic Paraplegia (HSP) is a degenerative disease of genetic origin affecting the corticospinal tracts in the spinal cord. There are three forms of inheritance: Autosomal dominant HSP, Autosomal rececive HSP and X-linked HSP.

This disease is characterized by progressive spasticity of leg muscles with varying degrees of stiffness and weakness of other muscle groups. In this review, we will discuss the latest findings on the pathophysiology of axonal degeneration and all the responsible genetic defects in HSP.

Item Type: Article
Subjects: AP Academic Press > Medical Science
Depositing User: Unnamed user with email support@apacademicpress.com
Date Deposited: 03 Feb 2023 09:33
Last Modified: 17 Jul 2024 09:26
URI: http://info.openarchivespress.com/id/eprint/394

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