Hasan TONEKABONI, Seyyed (2010) Hereditary Spastic Paraplegia: From Gene to Clinic. Iranian Journal of Child Neurology, 3 (4). pp. 7-16.
Text
1531-Article Text (Word file)-4217-1-10-20100405.pdf - Published Version
Download (187kB)
1531-Article Text (Word file)-4217-1-10-20100405.pdf - Published Version
Download (187kB)
Abstract
Objective
Hereditary Spastic Paraplegia (HSP) is a degenerative disease of genetic origin affecting the corticospinal tracts in the spinal cord. There are three forms of inheritance: Autosomal dominant HSP, Autosomal rececive HSP and X-linked HSP.
This disease is characterized by progressive spasticity of leg muscles with varying degrees of stiffness and weakness of other muscle groups. In this review, we will discuss the latest findings on the pathophysiology of axonal degeneration and all the responsible genetic defects in HSP.
Item Type: | Article |
---|---|
Subjects: | AP Academic Press > Medical Science |
Depositing User: | Unnamed user with email support@apacademicpress.com |
Date Deposited: | 03 Feb 2023 09:33 |
Last Modified: | 17 Jul 2024 09:26 |
URI: | http://info.openarchivespress.com/id/eprint/394 |