Antidiabetic and Antihyperlipidemic Activity of β-carotene on Streptozotocin-induced Diabetic Rats

Khanam, Khadiza and Mostofa Kamal, A. H. M. and Yeasmin, Mim and Rajia, Sultana (2022) Antidiabetic and Antihyperlipidemic Activity of β-carotene on Streptozotocin-induced Diabetic Rats. Journal of Pharmaceutical Research International, 34 (62). pp. 36-44. ISSN 2456-9119

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Abstract

Objective: A vital anti-oxidant, β-carotene has the capacity to reduce reactive oxidative stress, metabolic syndrome such as Type 2 (T2) Diabetes Mellitus (DM) and prevent inflammation, obesity, alzheimer and cardiovascular diseases in human. In this study, we evaluated the efficacy of β-carotene on streptozotocin (STZ)- induced T2DM rats.

Methods: Diabetes was induced in Wister rats through the intraperitoneal administration of STZ (50 mg/kg b.w.). Antihyperlipidemic activities of β-carotene were evaluated by oral dose (10 mg/70 kg b.w.) once daily for 21 days. Metformin (12.1 mg/kg b.w.) was used as a positive control.

Results: Blood samples of rats were drawn by tail vein puncture and cardiac puncture to determine the fasting blood glucose (FBG) and serum level of total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL), respectively. The result of individual treatment of β-carotene and metformin significantly (p<0.001) reversed the diabetes induced increase in FBG, LDL, TC and TG, whereas pointedly increased the STZ-induced decrease in HDL, if compared to the diabetic control.

Conclusion: The monotherapy of β-carotene had important antidiabetic and antihyperlipidemic effects and provided a scientific rationale for their use in antidiabetic therapy as a potential antioxidant.

Item Type: Article
Subjects: AP Academic Press > Medical Science
Depositing User: Unnamed user with email support@apacademicpress.com
Date Deposited: 25 Jan 2023 11:38
Last Modified: 19 Jul 2024 07:33
URI: http://info.openarchivespress.com/id/eprint/361

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