Clinical characteristics and primary outcomes of patients with ANCA-associated vasculitis and central diabetes insipidus

Chen, Xin and Zhang, Shuo and Peng, Xia and Shi, Xiaoxiao and Wu, Haiting and Wen, Yubing and Qin, Yan and Tian, Xinping and Zhu, Huijuan and Chen, Limeng (2023) Clinical characteristics and primary outcomes of patients with ANCA-associated vasculitis and central diabetes insipidus. Frontiers in Endocrinology, 14. ISSN 1664-2392

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Abstract

Introduction: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterized by systemic small-vessel vasculitis and may rarely present as central diabetes insipidus (CDI). In this study, we aimed to determine the clinical characteristics and prognosis of patients with AAV-associated CDI.

Methods: This was a nested case-control study where AAV patients with CDI at the Peking Union Medical College Hospital were followed from January 2012 to April 2022. Case-control matching with AAV patients without CDI was performed (1:5), and participants were matched by age, sex, and AAV classification. We collected clinical data every 3–6 months and conducted a literature review using PubMed to identify relevant articles published from 1983–2022.

Results: Among 1203 hospitalized AAV patients, 16 patients with CDI were included (1.3%). The average age was 49 years, and men accounted for 56.3%. Granulomatosis with polyangiitis (GPA) accounted for 87.5% of patients. AAV patients with CDI had more ear, nose, and throat (ENT) (81.3%) involvement and less renal impairment than those in the control group (P<0.05). After a mean follow-up of four years, 50% of patients were in remission from AAV, 37.5% relapsed, and 12.5% died. Our literature review suggested that patients in Asian countries tend to be older men and have higher myeloperoxidase (MPO-ANCA) positivity than those in Western countries. Furthermore, proteinase 3 (PR3-ANCA) positivity may predict disease recurrence.

Discussion: AAV patients with CDI had more ENT involvement and a higher eGFR. MPO-ANCA positivity is more commonly observed in Asian countries than Western countries, and PR3-ANCA positivity may predict recurrence.

Item Type: Article
Subjects: AP Academic Press > Mathematical Science
Depositing User: Unnamed user with email support@apacademicpress.com
Date Deposited: 05 Jul 2023 04:14
Last Modified: 17 Oct 2024 03:57
URI: http://info.openarchivespress.com/id/eprint/1710

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