Seroprevalence of Human Herpes Virus 8 among Blood Donors in National Blood Centre, Kuala Lumpur, Malaysia

Seong, K. Wooi and Asiah, M. Nor and Normi, M. and Aliza, M. Y. and Norhanim, A. and Yasmin, A. and Syimah, A. T. Nur and Roslaili, K. and Narazah, M. Y. (2014) Seroprevalence of Human Herpes Virus 8 among Blood Donors in National Blood Centre, Kuala Lumpur, Malaysia. International Blood Research & Reviews, 2 (4). pp. 149-159. ISSN 23217219

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Abstract

Aims: In South East Asia, there is no regional or local HHV-8 seroprevalence data on blood donors. Thus this study was aimed to determine the seroprevalence of HHV-8 among blood donors in National Blood Centre, Kuala Lumpur (NBCKL) and to test its association with donor socio demographic and transfusion transmitted infection (TTI) seropositivity.

Study Design: A cross sectional study.

Place and Duration of Study: National Blood Centre, Kuala Lumpur (NBCKL). Duration of the study from January 2008 to June 2009.

Methodology: A total of 761 serum samples were collected of which 670 from blood donors who were non-reactive for TTIs while 91 were from blood donors who were reactive for TTIs were tested for HHV 8 using BIOTRIN HHV-8IgG EIA kit and BIOTRIN HHV-8IgG Immuno fluorescent assay (IFA).

Results: The HHV-8 seroprevalence among blood donors in NBCKL was 1.3% (10/761) of which 0.9% (6/670) among healthy blood donors and 4.4% (4/91) among TTI seropositive donors. TTI seropositivity (p=0.023) and gender (p=0.018) shows a significant risk factors contributed to HHV-8 seropositivity. Human Immunodeficiency Virus (HIV) and Hepatitis C were associated with an increased risk of HHV-8 seropositivity (OR 6.8; 95% CI, 0 to 0.2 and OR 10.0; 95% CI, 0.1 to 0.4 respectively).

Conclusion: HHV-8 has a low seroprevalance among blood donors in the NBCKL with a male predominance. A donor with seropositivity for TTI, is associated with a higher risk HHV-8 seropositivity.

Item Type: Article
Subjects: AP Academic Press > Medical Science
Depositing User: Unnamed user with email support@apacademicpress.com
Date Deposited: 11 Jul 2023 04:30
Last Modified: 19 Oct 2024 03:48
URI: http://info.openarchivespress.com/id/eprint/1513

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