Vitamin D Status, Autonomic Nervous System Activity, and Cardiometabolic Risk

Lopez, Johanna and Campa, Adriana and Huffman, Fatma G. and Liuzzi, Juan P. and Li, Tan and Martinez, Ana H. and Ferris, Serena M. and Lantigua, Laura and Farooqi, Ashar and Rasul, Ammar and Atlas, Steven E. and Tiozzo, Eduard and Konefal, Janet and Woolger, Judi M. and Simoes, Herbert G. and Lewis, John E. (2017) Vitamin D Status, Autonomic Nervous System Activity, and Cardiometabolic Risk. Open Journal of Internal Medicine, 07 (03). pp. 37-51. ISSN 2162-5972

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Abstract

Vitamin D and its association with cardiovascular disease (CVD) are currently a topic of investigation. The objective of this study was to explore the association between vitamin D status (serum 25-hydroxyvitamin D (25(OH)D)) and a cardiometabolic risk score (CMRS) derived from markers of cardiac autonomic nervous system activity, vascular dynamics, and body composition, using an innovative non-invasive technology. We found that individuals who were vitamin D sufficient ((25(OH)D) ≥ 30 ng/ml, n = 51), compared to those who were vitamin D insufficient (<30 ng/ml, n = 44), had significantly higher heart rate variability (as measured by time and frequency domain variables) and lower photoplethysmography analysis markers and CMRS. These outcomes show that vitamin D insufficient subjects had reduced cardio protective parasympathetic nervous system activity, increased endothelial dysfunction, and hence were at greater cardiometabolic risk, implying vitamin D may play a meaningful role in CVD.

Item Type: Article
Subjects: AP Academic Press > Medical Science
Depositing User: Unnamed user with email support@apacademicpress.com
Date Deposited: 10 Jun 2023 05:55
Last Modified: 19 Jun 2024 11:58
URI: http://info.openarchivespress.com/id/eprint/1491

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