The Role of Indirect Immunofluorescence Methods in the Detection of Autoimmune Antibodies in Thyroid Disease

Kadi, Nourdin and Kayali, Lina (2017) The Role of Indirect Immunofluorescence Methods in the Detection of Autoimmune Antibodies in Thyroid Disease. Journal of Advances in Medicine and Medical Research, 24 (3). pp. 1-6. ISSN 24568899

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Abstract

Aims: In this study, we evaluated the prevalence of antithyroglobulin antibodies (anti-Tg Ab) and antipyroxidase antibodies (anti-TPO Ab) in thyroid disease and investigated the role of indirect immunofluorescence methods in its detection.

Study Design: The study was carried out on 87 patients with thyroid disorders.

Place and Duration of Study: The patients were recruited from the Department of Internal Medicine and the Department of Surgery at Aleppo University Hospital. A group of 25 matched volunteers were included as a control group for the investigation. Data analyzed in this study was collected over the period from December 2005 to February 2006.

Methodology: Immunofluorescence methods were used to study the prevalence of antithyroglobulin antibodies (anti Tg Ab) and anti pyroxidase antibodies (anti TPO Ab) in patients with different thyroid diseases.

Results: We found that anti-Tg Ab was positive in 33% of patients with goiters, 40% of patients with hyperthyroidism, 73% of patients with Hashimoto's thyroiditis, and 25% of patients with nodules. Anti-Tg Ab was positive in only 4% of the control group. Similarly, anti-TPO Ab was positive in 37% of patients with goiters, 73% of patients with hyperthyroidism, 88% of patients with Hashimoto's thyroiditis, and 50% of patients with nodules. Anti-TPO Ab was found positive in 8% of the control group.

Conclusion: Taken together, these results suggest anti-Tg Ab and anti-TPO Ab measurements are an important step in the evaluation and management of thyroid disorders. Anti-TPO Ab had the highest sensitivity in predicting thyroidal disorders. Immunofluorescence techniques, furthermore, were found to be a reliable method for the evaluation of these disorders.

Item Type: Article
Subjects: AP Academic Press > Medical Science
Depositing User: Unnamed user with email support@apacademicpress.com
Date Deposited: 20 May 2023 04:59
Last Modified: 15 Oct 2024 10:16
URI: http://info.openarchivespress.com/id/eprint/1183

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