Study of respiratory chain dysfunction in heart disease

Hassanpour, Seyyed Hossein and Dehghani, Mohammad Amin and Karami, Seyyedeh Zeinab (2018) Study of respiratory chain dysfunction in heart disease. Journal of Cardiovascular and Thoracic Research, 10 (1). pp. 1-13. ISSN 2008-5117

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Abstract

The relentlessly beating heart has the greatest oxygen consumption of any organ in the body at rest reflecting its huge metabolic turnover and energetic demands. The vast majority of its energy is produced and cycled in form of ATP which stems mainly from oxidative phosphorylation occurring at the respiratory chain in the mitochondria. A part from energy production, the respiratory chain is also the main source of reactive oxygen species and plays a pivotal role in the regulation of oxidative stress. Dysfunction of the respiratory chain is therefore found in most common heart conditions. The pathophysiology of mitochondrial respiratory chain dysfunction in hereditary cardiac mitochondrial disease, the aging heart, in LV hypertrophy and heart failure, and in ischaemia-reperfusion injury is reviewed. We introduce the practicing clinician to the complex physiology of the respiratory chain, highlight its impact on common cardiac disorders and review translational pharmacological and non-pharmacological treatment strategies.

Item Type: Article
Subjects: AP Academic Press > Medical Science
Depositing User: Unnamed user with email support@apacademicpress.com
Date Deposited: 03 May 2023 05:37
Last Modified: 06 Jul 2024 06:52
URI: http://info.openarchivespress.com/id/eprint/1146

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