Protective Roles of Kolaviron Extract from Garcinia kola Seeds against Isoniazid-induced Kidney Damage in Wistar Rats

Background: Garcinia kola seeds have been observed to be medically important and kolaviron, a bioflavonoid obtained from the seeds was studied for its biological activities. The study investigated the protective effect of kolaviron extract obtained from the seed of Garcinia kola against isoniazid-induced kidney damage.

Methodology: Kolaviron was extracted from fresh seeds of Garcinia kola (2 kg) using soxhlet extractor and partitioned with chloroform. Nephrotoxicity was induced in wistar rats by oral administration of isoniazid (20 mg/kg bwt) while kolaviron was administered on wistar rats an hour before isoniazid administration and lasted for 30 days. Protective effect of kolaviron was measured in the plasma of wistar rats by estimating the levels of key metabolites used as kidney biomarkers which are total protein, creatinine, urea and uric acid concentration.

Results: The isoniazid-treated group showed a significant (p < 0.05) decrease in total protein concentration of 3.57 ± 0.12 (mg/dl) while there was a significant (p < 0.05) increase in urea, uric acid and creatinine concentrations with values of 70.30 ± 4.77, 55.71 ± 11.15 and 18.04 ± 5.33 (mg/dl) respectively. However, kolaviron-treated group showed a remarkable increase (6.15 ± 0.96) in total protein concentration while urea, uric acid and creatinine concentrations significantly decreased to 45.25 ± 2.29, 35.60 ± 11.01 and 13.28 ± 4.41 (mg/dl) respectively.